Sounds like something you'd need to fudge with to 'fake it' so to speak. Might want to consider using some compositing in such a shot, too.

My best guess would be to animate text melting using blend shapes or lattices (or both), animate a puddle mesh forming to cover the text mesh, then animate a hand mesh coming from the puddle. If all could have the same shader, it would help sell it, otherwise, you might want to use compositing to help blend the three different models together.