So it looks like your control curves aren't influencing your mesh, but other than that, there's no information. You might not know what to call the problem, but you can describe it. How did you get to this point? What kind of rig/project are you using? Did you reference it? Did you scale it? Does this only happen at frame 181 or does it look like this when you open the file? Is the skeleton with the mesh or the control curves?