SPOILERS!









So, here are the Spider-Man 3 villain theories:

1) The Green Goblin returns. A bit too obvious from the ending of SM2. I hope they don't and let that sub-plot stew a bit until SM4.

2) The Lizard. Professor Conners, with his (too subtle) missing arm. In the comics, he attempts to grow his arm back using reptile cells and manages to turn himself into a big lizard-man. Might be cool.

3) Venom. In the comics, Venom is a symbiotic alien from space that Spidey picks up in one of his few galactic adventures. This doesn't seem plausible for the film, so the theory is that John Jameson, the astronaut, might have picked it up while in space. Having been stood up by MJ at the alter, he'd definitely have motivation for deciding to go after Peter. I personally hope for this one.