In my posted image, the top of the hand obviously isn't done, but it shows the idea.

The UV's that are closer to the fingers have been laid out, and you can see that I've tried to keep the 1x1 "checker" appearance.

Again, you don't have to use the checker texture; numbered boxes work perfectly fine. The idea remains the same; keep them uniform (looking like squares) as much as you can over an awkward surface.