I'd have to agree with ctbram re: acronis
I have a 15 TB NAS, configured as raid 6,
that everything gets backed up to on a daily basis.
Raid 6 because I have the ability to lose 2 drives at once, and still able to rebuild.
Have settled on Acronis after trying 1/2 dozen different programs,
and it seems to work the best, with the best options and compression.
*edit* of course mine is also a Windows system.