im not sure what appleseed uv seen but the one iv seen is all in 3d only with great cartoon like shaders. Thats why all the animation is so smooth. Look at other 2d animes and the animations r jerky because everthing is done by hand and then put through computers for editing.
Dont know how many appleseeds r out there.
I think everyone in this thread is just saying what animations they like (2d and 3d).
Family Guy and American Dad r the most random hilarious cartoons i have ever seen.

The first time i watch American Dad i didnt think it was that good but maybe it was just the one ep.
I cant believe how funny Spongebob can be for a kids cartoon.