One of my artists is a Z-Brush maniac. The basic workflow for him is to create a lowpoly model (organic or not) in Maya...then export it to Z-Brush....where he then uses the scuptural tools to add all the details.

It's lighting and rendering does leave the app a little wanting...however, it's terrific for texturing.

He then exports the model out to Maya and incorporates it into our scenes. The mesh together perfectly and we haven't run into any compatability issues at all.

Z-Brush is better used with a tablet....so, unless you have one you may want to rethink things a bit.

Hope that helps!
Cheers