Might be best smoothing during render. Then you can keep your scene nice and light, plus it make it easy to edit and make large changes to the UVs if you notice something later.
www.stevenegan-cgi.com
"Your weapons are no match for ours! People of Mars, surrender!"
"Um, this isn't Mars. This is Earth."
"Earth? Earth-with-nuclear-weapons Earth?"
"Yes."
[long pause] "Friend!!"