i would in this case not use dynamics but simple deformers.
- select the tube, then deform>sculpt deformer,
then parent the sculpt deformer to the sphere going through the tube.
then just animate the sphere and the sculpt deformer will deform the tube as it goes along the path.
be sure to make the sculpt slightly larger than the sphere so that the sphere is siting inside it to give u enough room to make it look like as if the sphere is deforming the tube.