Have you checked your hard drives - eg are they full. I had my cache going to the default area of my hard drive for a smoke sim and it kept crashing out - it turns out the cache need ed 220 gigs of hard drive space and filling up my C:\ - moving the file to my 2TB drive solved my problem.
I hope its as simple as that for you aswell
So, the system didn't crash this time but, it would take close to 24hrs to finish cashing the 2000-frame animation. I think I'm gonna have to quit on n-cloth and just skin the cloth to the character because I don't think I can wait 24hrs everytime I make a troubleshoot of any part of the cloth.
The free space depends on the sim - It changes on a case by case basis.
My sim looked nice but dame was not expecting it to take up so much space.